Twin Reversed Arterial Perfusion Sequence (TRAP Sequence)

Twin reversed arterial perfusion sequence (TRAP sequence) occurs when one twin, lacking a functioning cardiac system, receives blood from the normally developing “pump twin” in a monochorionic pregnancy. This places an enormous demand on the heart, putting the pump twin at risk for cardiac failure. Left untreated, the pump twin will die in 50 percent to 75 percent of cases. At CHOP, TRAP sequence can be treated in utero using selective bipolar cord coagulation and radio frequency ablation (RFA) procedures.

The risk to the pump twin rises proportionately to the increasing size of the abnormally developing twin. TRAP sequence is also associated with excess amniotic fluid, caused by increased blood flow to the kidneys that results in overproduction of fetal urine (the primary source of amniotic fluid). This buildup of fluid may cause polyhydramnios, leading to premature rupture of the fetal membranes and preterm labor.

“Reversed arterial perfusion” is used to describe this condition because blood flow is opposite from the normal blood supply of the fetus. In TRAP sequence, blood enters the abnormal twin (also called the acardiac or acephalic twin) through the umbilical artery (which usually carries blood away from the fetus back to the placenta) and exits through the umbilical vein, which normally carries blood from the placenta to the fetus.

TRAP sequence affects approximately 1 percent of monochorionic pregnancies, with an incidence of 1 in 35,000 births.

  • Causes TRAP sequence is a rare complication of identical twinning. Although the initiating events are unclear, TRAP sequence is thought to result from communication between the blood vessels in the two fetal circulations as well as a cardiac problem in the recipient twin. The condition does not appear to run in families and there are currently no reports of recurrence in the same family.
  • DiagnosisBecause of the strain on the pump twin’s heart, every case of TRAP sequence should be evaluated by fetal echocardiography. The reversed arterial flow in the acardiac/acephalic twin should be documented using color flow Doppler.

    It is important to exclude a chromosomal abnormality prior to offering a fetoscopic procedure in TRAP sequence since the incidence of chromosomal abnormality in the pump twin may be as high as 9 percent. Over half of these pregnancies are complicated by polyhydramnios and 75 percent by preterm labor.

    The difference in fetal weight between the twins is predictive of outcome. When the acardiac/acephalic twin outweighs the pump twin by more than 50 percent, death occurs in 64 percent of cases. If the acardiac/acephalic twin outweighs the pump twin by more than 75 percent, death occurs in 95 percent of cases. Risk of pregnancy complication is related to the size of the abnormal fetus.


TRAP sequence requires occlusion and division of the cord due to the risk of cord entanglement. Fetal echocardiography is essential for monitoring the pump twin for signs of decompensation and possible intervention. At The Children’s Hospital of Philadelphia, we offer selective bipolar cord coagulation and radiofrequency ablation (RFA) procedures as treatment options for mothers carrying twins diagnosed with TRAP sequence.

The goal of fetal surgery is to interrupt blood supply to the non-viable twin. This reduces cardiac strain on the pump twin and increases his or her chance of survival.


About Daddys with Angels.

We began as a group for grieving fathers and men in families, but other family members asked to join us. We now also have a group for Families with Angels dads and other male family members and siblings under 18. We have experienced and live with the harsh pain of loss and we hope we can bring other comfort with what we do, To find us please search for us on face book or Hugs to you all and floaty kisses to all your angels. We retain the name Daddys With Angels.
This entry was posted in Uncategorized. Bookmark the permalink.

Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s